Neurodevelopmental hypothesis of schizophrenia
نویسندگان
چکیده
منابع مشابه
Neurodevelopmental hypothesis of schizophrenia
The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be...
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While multiple theories have been put forth regarding the origin of schizophrenia, by far the vast majority of evidence points to the neurodevelopmental model in which developmental insults as early as late first or early second trimester lead to the activation of pathologic neural circuits during adolescence or young adulthood leading to the emergence of positive or negative symptoms. In this ...
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A series of studies has shown that neonatal excitotoxic disconnection of the rat ventral hippocampus may serve as a heuristic model of schizophrenia. The model mimics a spectrum of neurobiologic and behavioural features of schizophrenia. It produces functional pathology in critical brain regions implicated in schizophrenia and connected with the hippocampal formation, namely, the striatum, nucl...
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The original neurodevelopmental hypothesis of schizophrenia presented by D.R. Weinberger in 1987 focused on pathogenesis and did not address etiology. Available evidence indicates that genetic factors are the principal cause of schizophrenia. It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. Recent advances i...
متن کاملNeurodevelopmental rat models of schizophrenia
Animal models are very valuable for biomedical research. They enable to disclose pathological processes of the diseases and their treatment possibilities. Development of appropriate animal models of complex neuropsychiatric disorders, such as schizophrenia, is challenging since many clinical symptoms are difficult to replicate and assess in animals. There is strong evidence that disturbed brain...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2011
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.110.084384